RESEARCH ARTICLE


Prevalence and Factors Associated with Acute Postoperative Pain after Emergency Abdominal Surgery



Ezra Ejegu Mehari1, Yosef Belay Bizuneh2, *, Demeke Yilkal Fentie2, Nurhusen Riskey Arefayne2
1 Department of Anesthesia, College of Medicine and Health Sciences, Dire Dawa University, Dire Dawa, Ethiopia
2 2Department of Anesthesia, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia


Article Metrics

CrossRef Citations:
0
Total Statistics:

Full-Text HTML Views: 155
Abstract HTML Views: 49
PDF Downloads: 122
ePub Downloads: 50
Total Views/Downloads: 376
Unique Statistics:

Full-Text HTML Views: 82
Abstract HTML Views: 42
PDF Downloads: 64
ePub Downloads: 41
Total Views/Downloads: 229



Creative Commons License
© 2022 Mehari et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Anesthesia, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; E-mail phanuelyosef@gmail.com


Abstract

Objective:

This study aimed to assess the prevalence and associated factors of acute postoperative pain after emergency abdominal surgery in the first 24 postoperative hours among adult patients.

Methods:

An institutional-based cross-sectional study was conducted on adult patients undergoing emergency abdominal surgery at the University of Gondar Comprehensive Specialized Hospital from March 1 to May 30, 2020. Data were collected by delivering questionnaires through interviews and reviewing the patients’ charts. Data were entered into Epi Info software, version 7.2, and analyzed by SPSS version 20. Logistic regression was applied to point out independent risk factors for postoperative acute pain. Variables with a p-value of < 0.05 were taken as significant.

Results:

165 patients participated in the study with a response rate of 98.2%. Among these, 75.8% [95% CI: (69.8%, 82.3%)] of patients experienced moderate to severe acute postoperative pain. Female gender [AOR:3.9, 95%CI: (1.22,12.5)], preoperative anxiety[AOR:4.4,95%CI:(1.74,11.1)],moderate to severe preoperative pain[AOR:5.79,95%CI:(2.08,16.1)], and incision length ≥10cms [AOR: 4.86, 95%(CI:1.88,12.5)], were significantly associated with moderate to severe acute postoperative pain.

Conclusions and Recommendations:

The prevalence of immediate postoperative pain following emergency abdominal surgery was found to be high in this study. Acute postoperative pain was substantially linked to the female sex, preoperative anxiety, preoperative pain, and an incision length of ≥10 cm. The prevalence of moderate-to-severe acute postoperative pain as well as the factors that contribute to it can be used to develop particular preventive strategies to reduce patient suffering.

Keywords: Acute postoperative pain, Associated factors, Pain incidence, Numerical rating scale, Abdominal surgery, Tissue damage.



1. INTRODUCTION

According to the International Association for the Study of Pain, pain is an unpleasant sensory and emotional experience related to actual or potential tissue damage.

Postoperative pain is the most common symptom encountered by hospitalized surgical patients. It is caused by the actual tissue damage with the release of chemical mediators from the abdominal incision wound. This pain may cause shallow breathing, atelectasis, retention of secretions, patient dissatisfaction, prolonged opioid use, the development of chronic postoperative pain, and increased medical costs. This increases the prevalence of postoperative morbidity and leads to delayed recovery [1, 2].

Acute postoperative pain after abdominal surgery can be a significant problem because it has been shown to alter the metabolic response, resulting in a delayed recovery with a longer stay and increased morbidity, as well as the development of a chronic pain state through the 'wind up' process and central sensitization [3, 4].

Within the first 24–48 hours after abdominal surgery, the prevalence of postoperative pain varies between studies. The proportion of patients experiencing moderate to severe pain 24 hours after abdominal surgery ranged from 22 to 67 percent [5-7]. According to studies conducted in developing nations, a significant rate of postoperative pain and poor postoperative management was seen [4, 8].

The most common predictors of severe pain reported include female sex, young age, preoperative severe pain, anxiety risks and problems, drug type and route of administration, type and duration of surgery, postoperative pain treatment, previous pain experiences, smoking, American Society of Anesthesiologist status, chronic pain, marital status, socioeconomic status, educational status, and surgical history [9-11].

Self-report is the most accurate form of pain assessment, and the numerical rating scale has strong sensitivity, validity, and reliability for pain assessment, as well as being widely validated across a variety of patient types [12, 13].

Experts recommend a thorough evaluation of patients and the use of multimodal strategies such as preoperative, intraoperative, and postoperative interventions; systemic analgesics; intrathecal administration of opioids; use of non-steroidal anti-inflammatory drugs; and various neuraxial and peripheral blocks as part of effective post-operative pain management [14, 15].

Studies on the incidence and factors associated with pain after emergency abdominal surgery are relatively scarce in Ethiopia. Hence, this study aimed to explore patients' experiences of pain and associated factors after emergency abdominal surgery. It will provide insight into patients' experiences of pain immediately after emergency abdominal surgery and pave the way for effective pain control, decreased hospital stay, and decreased cost of early discharge.

2. MATERIALS AND METHODS

2.1. Study Design, Period, and Area

An institutional-based cross-sectional study was conducted from March 1 to May 30, 2020. The study was conducted at the University of Gondar Comprehensive Specialized Hospital in the Post Anesthesia Care Unit and in the surgical ward. The University of Gondar Comprehensive Specialized Hospital is one of the greatest and most well-known hospitals in Ethiopia. It serves more than 5 million people as a referral for the district and other hospitals.

2.2. Sample Size Determination and Sampling Technique

2.2.1. Sample size

Since there is no study done in Ethiopia on the prevalence and associated risk factors of acute postoperative pain after emergency abdominal surgery, a single population proportion formula was used, and the sample size was calculated by taking the proportion of 50%, assuming a 95% confidence interval with a 5% margin of error, and finally, the sample size is calculated as:-

Since the total number of emergency abdominal surgeries in our hospital annually is below 10,000, a correction factor formula was used to get the exact sample size. In the University of Gondar Comprehensive Specialized Hospital, according to the Federal Democratic Republic of Ethiopia, Ministry of Health, University of Gondar Hospital operation room register book and record review, an average of 91 emergency abdominal operations were done in the main operation theatre per month [16]. Therefore the total sample size within the data collection period will be calculated as follows:

, Where: nF=Adjusted sample size, n= Initial sample size N=Population size, nF = , nF= 159.75, nF~160

When a 5% of nonresponse rate was added, the total number of patients who participated in the study was 168.

2.2.2. Sampling Technique

The convenience sampling method was used, consisting of consecutive patients undergoing emergency abdominal surgery who met the inclusion criteria and were expected to stay in hospital care for 24 hours.

2.3. Data Collection Tools and Procedures

After taking written consent from each patient to participate in the study, the patient’s socio-demographic data (age, sex, weight, Body Mass Index, religion, and ethnicity), ASA status, and type of procedure were recorded. Two data collectors were selected from among BSc anesthetists, and training was given before data collection. The data collection procedure included a chart review and an interview-based questionnaire. From the chart review, preoperative condition, intraoperative status, analgesic medications, and postoperative conditions were assessed and recorded. In the interview, participants were asked for the required data. The supervisor controlled the data quality and its completeness at the end of data collection for a single participant. The data collectors took informed consent, reviewed the chart, and documented the pain severity at rest and with movement by using NRS at 2, 12, and 24 hours postoperatively. At the same time, the analgesics were also documented. Data collections were done based on inclusion and exclusion criteria.

2.3.1. Questionnaire

A pretested and semi-structured questionnaire containing the numeric rating scale was used for assessing and measuring postoperative pain. The NRS was taken with 3 measurements in the first 24 hours of the postoperative period; 2 hours since the end of surgery and the return of full consciousness, the second on the 12th hour, and the third on the 24th hour. The patient’s ward and bed number were documented on the questionnaire before they left the recovery room and were followed to their respective wards for the 2nd and 3rd pain scores.

2.3.2. Chart review

Preoperative conditions, intraoperative status, analgesic medications, and postoperative conditions were assessed and recorded in the patient's chart.

2.3.3. Interview

The participants and/or available caregivers were asked for the required data.

2.4. Study Variables

2.4.1. Dependent Variable

Prevalence and associated factors of acute postoperative pain after emergency abdominal surgery.

2.4.2. Dependent Variable

Independent variables

2.4.2.1. Socio-demographic Characteristics

Age, sex, BMI, educational status, and marital status.

2.4.2.2. Preoperative Factors

Preoperative anxiety, preoperative analgesics, ASA status, preoperative pain, previous experience of operation, and sleeping disorder.

2.4.2.3. Intra-operative Factors

Type of abdominal surgery, type of incision, length of incision, type of anesthesia, surgical time, anesthesia time, intraoperative analgesics.

2.4.2.4. Postoperative Factors

Types of analgesics given in the postoperative period.

2.5. Data Quality Assurance

To ensure the quality of data, the pretest of the data collection was done on 5% of the samples of the patients who had undergone emergency abdominal surgery, which was not included in the main study, and the questionnaire was modified appropriately. The collected data were checked for completeness, accuracy, and clarity.

2.5.1. Data Quality Assurance

Inclusion and Exclusion criteria.

2.5.1.1. Inclusion Criteria

All general surgical patients with the age of ≥18 and ASA classification of I-III underwent emergency abdominal surgery.

2.5.1.2. Exclusion Criteria

Patients who have documented and newly diagnosed cognitive dysfunction and ongoing treatment of chronic pain, and patients who are unable to self-report pain.

2.6. Data processing and analysis

The collected data were checked manually for completeness and entered into Epi-info software version 7.2 and then exported to Statistical Package for Social Sciences version 20 computer program for analysis. Multicollinearity between independent variables was checked and there was no correlation (P>0.5). The association between independent factors and the outcome variable was determined by the chi-square test and bivariable and multivariable logistic regression. Crude and adjusted odds ratios were used to see the strength of the association for bivariable and multivariable logistic regression, respectively. A P-value of less than 0.05 was considered statistically significant.

3. RESULTS

3.1. Socio-demographic Characteristics of the Respondents

A total of 165 emergency abdominal surgical patients were recruited in the analysis with a 98.2% response rate. Three patients were excluded due to incomplete data because of missing measurement time points for pain scores. Age, sex, BMI, marital status, and level of education were assessed in this character. Males accounted for 115(69.7%) and females were 50(30.3%). The mean age ± Standard Deviation and mean BMI±SD of the participants were 34.69±14.97 and 21.39±2.62, respectively (Table 1).

3.2. Preoperative Factors

For preoperative factors, greater numbers of respondents were kept on ASA I & II; 133 (80.6%). More than half reported moderate to severe preoperative pain; 84 (50.9%) and 102 (61.8%) reported preoperative anxiety (Table 2).

Table 1. Socio-demographic characteristics of Patients with postoperative pain after emergency abdominal surgery in University of Gondar Comprehensive Specialized Hospital, Gondar; 2020, (n= 165).
Variables Category Frequency(N) Percentage (%)
Sex Male 115 69.7
Female 50 30.3
Age 18-39 104 63.0
40-59 45 27.3
≥60 16 9.7
BMI <18.5 20 12.1
18.5-24.9 137 83
25-29.9 7 4.2
≥30 1 0.6
Educational status Illiterate 47 28.5
Can read and write 27 16.4
Primary school(1-8) 37 22.4
Secondary school(9-12) 28 17.0
College and above 26 15.8
N = Number
Table 2. The preoperative factors associated with postoperative pain after emergency abdominal surgery in University of Gondar comprehensive specialized hospital, Gondar; 2020, (N= 165).
Variable & Category Frequency(N) Percentage (%) Post-operative pain in 24 hours
None-mild (N, %) Moderate-severe (N, %)
ASA- status
I & II 133 80.6 34(20.6%) 99(60.0%)
III 32 19.4 6(3.6%) 26(15.8%)
Preoperative analgesics given
Yes 47 28.5 24(14.5%) 23(13.9%)
No 118 71.5 16(9.7%) 102(61.8%)
Type of analgesics at the preoperative time
Tramadol 20 12.1 11(6.7%) 9(5.5%)
Diclofenac 18 10.9 9(5.5%) 9(5.5%)
Paracetamol 8 4.8 3(1.8%) 5(3.0%)
Diclofenac+PCM 1 0.6 1(0.6%) 0(0.0%)
Not given 118 71.5 16(9.7%) 102(61.8%)
Preoperative pain
Yes 84 50.9 7(4.2%) 77(46.7%)
No 81 49.1 33(20.0%) 48(29.1%)
PCM = Paracetamol N = Number

3.3. Intra-operative and Postoperative Factors

From the intraoperative factor distribution, a large proportion of patients, 93(56.4%), had undergone laparotomy and 66(40%) had undergone appendectomy, and 91(55.2%) of patients had an incision length of ≥10cm (Table 3).

Table 3. Intra-operative and postoperative factors associated with postoperative pain after emergency abdominal surgery in University of Gondar Comprehensive Specialized Hospital, Gondar; 2020, (N= 165).
Variables Frequency(N) Percentage (%) Postoperative pain within 24 hours
None-mild N (%) Moderate-Severe N (%)
Surgery Type
Laparatomy 93 56.4 16(9.7%) 50(30.3%)
Appendectomy 66 40 22(13.3%) 71(43.0%)
Cholecystectomy 6 3.6 2(1.2%) 4(2.4%)
Anesthesia Time (in Minutes)
<60 2 1.2 1(0.6%) 2(1.2%)
60-180 142 86.1 36(21.8%) 105(63.6%)
>180 21 12.7 3(1.8%) 18(10.9%)
Nerve Block Done
Yes 23 13.9 8(4.8%) 15(9.1%)
No 142 86.1 32(19.4%) 110(66.7%)
Type of Nerve Block
TAP 9 5.5 2(1.2%) 7(4.2%)
Infiltration 7 4.2 2(1.2%) 5(3.0%)
Rectus sheath 1 .6 1(0.6%) 0(0.0%)
Rectus sheath+TAP 5 3.0 2(1.2%) 3(1.8%)
Paravertebral 1 .6 1(0.6%) 0(0.0%)
Note done 142 86.1 32(19.4%) 110(66.7%)
Anesthesia Induction
Ketamine 132 80.0 33(20.0%) 99(60.0%)
Propofol 7 4.2 3(1.8%) 4(2.4%)
Ketofol 26 15.8 4(2.4%) 22(13.3%)
Postoperative Analgesics Given
Yes 113 68.5 30(26.5%) 83(73.4%)
No 52 31.5 28(44.2%) 35(67.3%)
Type of Postoperative Analgesics
Tramadol 59 35.8 18(10.9%) 41(24.8%)
Diclofenac 24 14.5 4(2.4%) 20(12.1%)
Diclofenac+tramadol 9 5.5 5(3.0%) 4(2.4%)
Fentanyl 18 10.9 3(1.8%) 15(9.1%)
Morphine 3 1.8 0(0.0%) 3(1.8%)
Abbreviation: TAP=The Transversus abdominis Plane, N=Number.
Fig. (1). Bar graph showing the percentage of systemic analgesia given in the postoperative period after emergency abdominal surgery in different time intervals: 2nd, 12th and 24th hours of study participants in University of Gondar Comprehensive Specialized hospital, 2020 (n=165).

3.4. Analgesics Were Given Postoperatively

Participants were given different types of systemic analgesia at different time gaps for the management of acute postoperative pain after emergency abdominal surgery. For that systemic analgesia, the combination of diclofenac and tramadol was frequently given (32.7%) and (45.6%) at the 2nd and 12th hours, respectively. Whereas, 30.9% and 32.1% of the participants did not take any systemic analgesia in the 2nd and 24th hours, respectively. Tramadol is given frequently in 36.4% and 34.5% in the 12th and 24th hours, respectively (Fig. 1).

3.5. Post-operative Pain Prevalence

At the 2nd postoperative hour, 89 (53.9%) of the participants reported moderate to severe pain, while 76 (46.1%) reported no to mild pain. At the 12th postoperative hour, most of the participants (123) reported moderate to severe pain. In the last 24 hours postoperatively, 70 (42.4%) of the participants experienced moderate to severe pain. Of the 113 patients who were given analgesics, 30 (26.5%) experienced non– mild pain and 83 (73.4%) experienced severe pain. Of the 52 patients who did not receive analgesics, 28 (44.2%) experienced non–mild pain and 35 (67.3%) had severe pain. Therefore, in this study, the overall prevalence of acute postoperative pain at 24 hours was 75.8% [95% CI: (69.8%, 82.3%)] with the numerical rating scale of the pain assessment method (Fig. 2).

3.6. Factors Associated with the Prevalence of Acute Postoperative Pain within 24 Hours

We analyzed the variables in both bivariable and multivariable logistic regression methods to control potential confounding factors and to determine the independent association between postoperative pain and factors of acute pain. With the bivariable analysis method, sex, age, preoperative pain, preoperative analgesics, preoperative anxiety, and incision length were significant with a P-value < 0.2 (Table 4).

On multivariable logistic regression analysis, the following variables were found to have moderate to severe pain in post-abdominal surgery; compared with males, females were 3.93 times more likely to have acute postoperative pain [AOR:3.93,95%CI:(1.22,12.5)]. Accordingly, participants who had anxiety in the preoperative period were 4.41 times more likely to have moderate to severe postoperative pain than those who were not anxious [AOR: 4.41, 95%CI:(1.74, 11.1)]. Similarly, the odds of having moderate to severe postoperative pain were 5.79 times [AOR: 5.79, 95%CI: (2.08, 16.1)] higher among participants who had moderate to severe preoperative pain than those participants who had no moderate to severe preoperative pain. The study also revealed that an incision length of ≥10 cm was 4.86 times [AOR: 4.86, 95%CI: (1.88, 12.5)] more likely to have moderate to severe acute postoperative pain compared to participants who had an incision length of <10cm (Table 4).

Fig. (2). Bar graph showing the percentage of acute postoperative pain reports after emergency abdominal surgery in different time intervals in University of Gondar Comprehensive Specialized hospital, Gondar, 2020, (n= 165).

Table 4. Factors Associated with Acute Postoperative Pain After Emergency Abdominal Surgery Analyzed in Bivariable and Multivariable Logistic Regression in University of Gondar Comprehensive Specialized Hospital, Gondar, 2020 (N=165).
Variables & Category Postoperative pain within 24 hours Odds ratio (95% CI)
None-mild N (%) Moderate-Severe N (%) Crude (95% CI) Adjusted (95%CI)
Sex
Male 34(20.6%) 81(49.1%) 1.00 1.00
Female 6(3.6%) 44(26.7%) 3.078(1.2,7.89)* 3.93(1.22,12.5)**
Age in Years
18-39 20(12.1%) 84(50.9%) 2.52 (0.81,7.75)* 1.58(6.88,0.36)
40-59 14(8.5%) 31(18.8%) 1.32 (0.40,4.37)* 0.80(0.14,4.37)
≥60 6(3.6) 10(6.1) 1.00 1.00
Preoperative Pain
No 33(20.0%) 48(29.1%) 1.00 1.00
Yes 7(4.2%) 77(46.7%) 7.56(3.1,18.4)* 5.79(2.08,16.1)**
Preoperative Analgesics
Yes 24(14.5%) 23(13.9%) 1.00 1.00
No 16(9.7%) 102(61.8%) 1.63(0.78,3.39) * 1.26(0.48,3.29)
Preoperative Anxiety
No 28(17.0%) 35(21.2%) 1.00 1.00
Yes 12(7.3%) 90(54.5%) 6(2.748,13.10)* 4.41(1.74,11.1)**
Incision Length in Centimeters
<10 30(18.2%) 44(26.7%) 1.00 1.00
≥10 10(6.1%) 81(49.1%) 5.5(2.47,12.34)* 4.86(1.88,12.5)**
*=Variables significant in the bi-variable logistic regression analysis (p<0.2).
**=Variables significant in the multivariable logistic regression analysis (p<0.05), N=Number
1.00=Reference/indicator.

4. DISCUSSION

Based on these findings, the overall prevalence of moderate to severe acute postoperative pain after emergency abdominal surgery was 75.8% [95% CI:(69.8%, 82.3%)]. This finding was consistent with the study conducted in South Africa, which was 79% [17] and a study in Iran, Kerman’s teaching hospital, which was 78.3% [18], and a study conducted in Queensland, Australia, which was 73.5% [19]. Our result was also supported by a study done in the USA, which showed that more than 80% of patients complain of pain during the postoperative period, with 75% rating it as moderate, severe, or extreme [20].

However, this finding was lower than a study conducted in Jimma, Ethiopia, which reported that moderate-severe pain was 88.2% [21] and a cohort study in Danish patients, which reported 83.3% after gastrointestinal surgeries [22]. This disparity could be related to insufficient pain treatment, such as when present, analgesia is insufficient to relieve pain for long periods or when breakthrough pain is not properly managed.

This result was also higher than that of two earlier studies done in Kenya, one of which had a 48% result and the other had a 56.2% result [23, 24]. A study conducted in Iran showed 62% [25] result and a study in Turkey found 68.9% result [26]. This difference may result from the use of preoperative counselling, multimodal analgesia, and sufficient epidural analgesia for pain control. This result was also higher than a study conducted in Spain, which ranged from 22 to 67% [6] and in the Netherlands, which ranged from 30–55% [14]. This discrepancy might be due to adequate pain assessment, documentation, and management of pain with different analgesic modalities.

Females were 3.93 times more likely than males to experience moderate to severe acute postoperative pain, according to several studies. This finding was consistent with the study conducted in Germany and the USA [27-29]. Females were experiencing moderate to severe postoperative pain compared to males. The reason for this might be due to the fact that females are at greater risk of experiencing many forms of clinical pain and are more sensitive to experimentally induced pain than males. Compared to females, males exhibited less negative pain responses when focusing on the sensory component of pain [30-32].

The study demonstrates a relationship between preoperative anxiety and postoperative pain prevalence. Those participants who had anxiety in the preoperative period were 4.4 times more likely to have moderate to severe postoperative pain compared to those who were not anxious. This finding was supported by a study done in Brazil, which revealed that patients who were anxious in the preoperative period had moderate to severe postoperative pain as compared to non-anxious patients. This might be due to the reason that psychological characteristics like anxiety and fear of pain predict postsurgical pain and have been shown to be significantly associated with postoperative pain after abdominal surgery, and an anxious state has been advocated as a factor in lowering pain threshold, facilitating overestimation of pain intensity [33]. Psychological distress, such as preoperative anxiety, has a negative effect and can increase postoperative analgesic consumption. Normally, the mild level of preoperative anxiety has not been identified or recognized as having critical repercussions, especially in patients without a psychiatric diagnosis [11, 34]. According to this study, patients who had moderate to severe pain preoperatively had moderate to severe acute postoperative pain compared to those who did not. This conclusion was supported by research conducted in Brazil and Canada [11, 35]. This might be due to patients with pain prior to surgery displaying increased sensitization to peripheral nociceptors and exaggerated sensory pain input through the release of inflammatory mediators such as prostaglandin E2 and nerve growth factor and opioid-induced hyperalgesia [36-38]. Pain perception may also be influenced indirectly when patients expect to recover from surgery and return to daily routines with little inference from pain, and negative emotional states following surgery may be less apparent and less likely to exacerbate pain intensity [39, 40].

An incision length of ≥ 10cms was 4.86 times more likely to have acute postoperative pain compared to an incision length of <10cms. This result was supported by a study done in Ethiopia and in the Netherlands [41, 42]. Skin incision-related processes lead to inflammation and sensitization of the peripheral and central neurons, thus accelerating a concomitant neurophysiologic stress response that will increase postoperative pain [43].

5. LIMITATIONS OF THE STUDY

The preoperative poor documentation system gave analgesics on the chart; this means the documentation may not be appropriate on the patient's chart even when the drug was given.

CONCLUSION AND RECOMMENDATIONS

The prevalence of immediate postoperative pain following emergency abdominal surgery was found to be high in this study. Acute postoperative pain was substantially linked to the female sex, preoperative anxiety, preoperative pain, and an incision length of 10 cm. The prevalence of moderate-to-severe acute postoperative pain, as well as the factors that contribute to it, can be used to develop particular preventive strategies to reduce patient suffering.

LIST OF ABBREVIATIONS

ASA = American Society of Anesthesiology
BMI = Body Mass Index
CI = Confidence Interval
NRS = Numerical Rating Scale
RCT = Randomized Control Trial
UoGCSH = University of Gondar Comprehensive Specialized Hospital
AOR = Adjusted Odds Ratio
NSAIDs = Non-Steroidal Anti -Inflammatory Drugs
SPSS = Statistical Package for the Social Sciences
USA = United States of America

AUTHORS’ CONTRIBUTIONS

All authors made a significant contribution to the work reported, whether that is, in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

ETHICS APPROVAL AND CONSENT TO PARTICIPATE

Ethical clearance was obtained from the ethical review committee of the School of Medicine, University of Gondar. An official permission letter was obtained from the University of Gondar comprehensive specialized hospital administrator, to conduct research. The purpose and benefit of the study were explained to the patients.

HUMAN AND ANIMAL RIGHTS

No animals were used that are the basis of the study. All human procedures were performed in accordance with guidelines of the principles of the Declaration of Helsinki 1964.

CONSENT FOR PUBLICATION

Written informed consent was taken from all study subjects to secure the confidentiality of patient information.

STANDARDS OF REPORTING

STROBE guidelines were followed.

AVAILABILITY OF DATA AND MATERIALS

This published article contains all data generated or analyzed during this study.

FUNDING

None.

CONFLICT OF INTEREST

The authors declare that they have no conflicts of interest regarding the publication of this paper.

ACKNOWLEDGMENTS

The authors’ deepest gratitude goes to the University of Gondar, College of Medicine and Health Sciences, for helping them conduct this research. The authors also appreciate their data collectors for their enthusiastic and energetic participation in the process of data gathering. Finally, the authors extend their gratitude to the study participants who spent their precious time responding to their questionnaires.

REFERENCES

[1] Padmaja R, HaranathBabu J.T., Post operative analgesia after abdominal surgery and its management in our hospital. Int J Pharm Biol Sci 2014; 4(4): 35-42.
[2] Chanif C, Petpichetchian W, Wimo W. Acute postoperative pain of Indonesian patients after abdominal surgery. Nurse Med J Nurs 2012; 2(2): 409-20.
[3] Ahmad Al Samaraee, G.R., Usama Saleh, Vish Bhattacharya, Factors contributing to poor post-operative abdominal pain management in adult patients: A review. The Surgeon Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 2009; 151-8.
[4] Mohamed Nagi ME. Postoperative pain in abdominal surgery: The proper management. Int J Med Health Res 2016; 2(8): 49-51.
[5] Gagliese L, Weizblit N, Ellis W, Chan VWS. The measurement of postoperative pain: A comparison of intensity scales in younger and older surgical patients. Pain 2005; 117(3): 412-20.
[6] Aguilera C, Arnau JM, Baños J-E, Laporte J-R. Management of postoperative pain in abdominal surgery in Spain. A multicentre drug utilization study. Br J Clin Pharmacol 1999; 47(6): 667-73.
[7] Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg 2003; 97(2): 534-40.
[8] Masigati HG, Chilonga KS. Postoperative pain management outcomes among adults treated at a tertiary hospital in Moshi, Tanzania. Tanzan J Health Res 2014; 16(1): 47-53.
[9] Chou R, Gordon DB, de Leon-Casasola OA, et al. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists’ Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain 2016; 17(2): 131-57.
[10] Sanansilp V, Dejarkom S, Deetayart S. Postoperative pain management and the risk factors in major operation: a baseline study of acute pain service, Siriraj Hospital. J Med Assoc Thai 2016; 99(5): 549-56.
[11] Yang MMH, Hartley RL, Leung AA, et al. Preoperative predictors of poor acute postoperative pain control: a systematic review and meta-analysis. BMJ Open 2019; 9(4)e025091
[12] Amelia Williamson MSc, R., PGCE, Pain: A review of three commonly used pain rating scales. Issues in clinical nursing 2004.
[13] Karcioglu O, Topacoglu H, Dikme O, Dikme O. A systematic review of the pain scales in adults: Which to use? Am J Emerg Med 2018; 36(4): 707-14.
[14] M. Sommer*, J.M.d.R., M. van Kleef*, A. G. H. Kesselsy, M. L. Petersz, J. W. J. M. Geurts* H.-F. Gramke*, M. A. E. Marcus, The prevalence of postoperative pain in a sample of 1490 surgical inpatients. Eur J Anaesthesiol 2008; 25: 267-74.
[15] Campagna S, Antonielli Doulx, paradiso R, et al. Postoperative pain, an unmet problem in day or overnight Italian surgery patients: A prospective study. Pain Res Manag 2016; 6104383.
[16] FDRE, M., University of Gondar Hospital, operation room register book. record review, from November 25-December 25, 2019.
[17] Murray AA, Retief FW. Acute postoperative pain in 1 231 patients at a developing country referral hospital: Incidence and risk factors. South Afri J Anaes Anal 2016; 22(1): 19-24.
[18] Tavakoli n, Mehrdad N, Efat HZ. Patients’ satisfaction from pain soothing after the surgery in kerman hospitals (2005). J kermanshah uni med sci 2007; 11(2): 33.
[19] Schoenwald A, Clark CR. Acute pain in surgical patients. Contemp Nurse 2006; 22(1): 97-108.
[20] Gordon DB, de Leon-Casasola OA, Wu CL, Sluka KA, Brennan TJ, Chou R. Research gaps in practice guidelines for acute postoperative pain management in adults: Findings from a review of the evidence for an american pain society clinical practice guideline. J Pain 2016; 17(2): 158-66.
[21] Eshete MT, Baeumler PI, Siebeck M, et al. The views of patients, healthcare professionals and hospital officials on barriers to and facilitators of quality pain management in Ethiopian hospitals: A qualitative study. PLoS One 2019; 14(3): e0213644.
[22] Lorentzen V, Hermansen IL, Botti M. A prospective analysis of pain experience, beliefs and attitudes, and pain management of a cohort of Danish surgical patients. Eur J Pain 2012; 16(2): 278-88.
[23] Sindhu1, N.A., Nalini3, Observational study to assess the effectiveness of post-operative pain management of patients undergoing major abdominal surgeries in a tertiary care hospital. IAIM 2019; 6(5): 98-103.
[24] Ocitti EF, Adwok JA. Post-operative management of pain following major abdominal and thoracic operations. East Afr Med J 2000; 77(6): 299-302.
[25] Shahdadi H, Balouchi A, Taheri S, Darban F. Der Pharmacia Lettre, Study effect of mint essence on pain, bloat and nausea in patients undergoing appendectomy 2015; 7(10): p.:193-97.
[26] Ayhan Fatma MDoN. Karamanoglu Mehmet Bey University, Karaman, Turkey Kursun Serife, PhD Selcuk University, Faculty of Health Science, Surgical Nursing, Konya, Turkey, Experience of Pain in Patients Undergoing Abdominal Surgery and Nursing Approaches to Pain Control. Int J Caring Sci 2017; 10(3): 1456.
[27] Wei Mei, M. Seeling, M. Franck, F. Radtke , B. Brantner, K-D Wernecke, C. Spies. Independent risk factors for postoperative pain in need of intervention early after awakening from general anaesthesia. Eur J Pain 2009; 14(2): 149e1-7.
[28] Zalon ML. Mild, moderate, and severe pain in patients recovering from major abdominal surgery. Pain Manag Nurs 2014; 15(2): e1-e12.
[29] Tighe PJ, Riley JL III, Fillingim RB. Sex differences in the incidence of severe pain events following surgery: a review of 333,000 pain scores. Pain Med 2014; 15(8): 1390-404.
[30] Cepeda MS, Carr DB. Women experience more pain and require more morphine than men to achieve a similar degree of analgesia. Anesth Analg 2003; 97(5): 1464-8.
[31] Barsky AJ, Peekna HM, Borus JF. Somatic symptom reporting in women and men. J Gen Intern Med 2001; 16(4): 266-75.
[32] Aubrun F, Salvi N, Coriat P, Riou B. Sex- and age-related differences in morphine requirements for postoperative pain relief. Anesthesiology 2005; 103(1): 156-60.
[33] Gatti AP. Review of Predictors of Postoperative Pain 2018; 1.
[34] Bradshaw P, Hariharan S, Chen D. Does preoperative psychological status of patients affect postoperative pain? A prospective study from the Caribbean. Br J Pain 2016; 10(2): 108-15.
[35] Caumo W, Schmidt AP, Schneider CN, et al. Preoperative predictors of moderate to intense acute postoperative pain in patients undergoing abdominal surgery. Acta Anaesthesiol Scand 2002; 46(10): 1265-71.
[36] Ismail S, Siddiqui A, Rehman A. Postoperative pain management practices and their effectiveness after major gynecological surgery: An observational study in a tertiary care hospital. J Anaesthesiol Clin Pharmacol 2018; 34(4): 478-84.
[37] Pogatzki-Zahn EM, Segelcke D, Schug SA. Postoperative pain—from mechanisms to treatment. Pain Rep 2017; 2(2): e588-8.
[38] Wang Y, Liu Z, Chen S, et al. Pre-surgery beliefs about pain and surgery as predictors of acute and chronic post-surgical pain: A prospective cohort study. Int J Surg 2018; 52: 50-5.
[39] Robleda G, Sillero-Sillero A, Puig T, Gich I, Baños JE. Influence of preoperative emotional state on postoperative pain following orthopedic and trauma surgery. Rev Lat Am Enfermagem 2014; 22(5): 785-91.
[40] Nicholas MK. The pain self-efficacy questionnaire: Taking pain into account. Eur J Pain 2007; 11(2): 153-63.
[41] Kalkman JC, Visser K, Moen J, Bonsel JG, Grobbee ED, Moons MKG. Preoperative prediction of severe postoperative pain. Pain 2003; 105(3): 415-23.
[42] Admassu WS, Hailekiros AG, Abdissa ZD. Severity and risk factors of post-operative pain in University of Gondar Hospital, Northeast Ethiopa. J Anesth Clin Res 2016; 7(10): 675.
[43] Ioannidis A, Arvanitidis K, Filidou E, et al. The Length of Surgical Skin Incision in Postoperative Inflammatory Reaction. JSLS 2018; 22(4): p. e2018.00045.