RESEARCH ARTICLE
Changes in TRP Channels Expression in Painful Conditions
Mahendra Bishnoi1, Louis S. Premkumar2, *
Article Information
Identifiers and Pagination:
Year: 2013Volume: 6
First Page: 10
Last Page: 22
Publisher ID: TOPAINJ-6-10
DOI: 10.2174/1876386301306010010
Article History:
Received Date: 09/08/2012Revision Received Date: 09/08/2012
Acceptance Date: 16/08/2012
Electronic publication date: 08/3/2013
Collection year: 2013
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Over the last fifteen years after the successful cloning of the first nociceptive Transient Receptor Potential (TRP) channel, TRP Vanilloid 1, other members of the TRP channel family have been cloned, characterized and implicated in different modalities of pain. Tremendous progress has been made with regard to the specific role of these TRP channels in nociception using electrophysiological and molecular methods, along with behavioral models combined with gene disruption techniques. This review summarizes the evidence supporting the role of TRP channels (TRP Vanilloid 1, TRP Vanilloid 2, TRP Vanilloid 3, TRP Vanilloid 4, TRP Ankyrin 1, TRP Melastatin 2, TRP Melastatin 3, TRP Melastatin 8, TRP Mucolipin 3 and TRP Canonical 1, 6) involved in nociception. The review also highlights the current status and future avenues for developing TRP channel modulators as analgesic agents.
