RESEARCH ARTICLE


Treatment of Chronic Fatigue Syndrome and Fibromyalgia with D-Ribose– An Open-label, Multicenter Study



Jacob Teitelbaum*, 1, Janelle Jandrain2, Ryan McGrew3
1 Kona Research Center, 76-6326 Kaheiau St, Kailua Kona, Hawaii 96740, and Fibromyalgia and Fatigue Centers, Addison, Texas, USA
2 Schwabe North America, 3051 West Maple Loop Dr., Lehi, UT 84043, USA
3 Schwabe North America, 3051 West Maple Loop Dr., Lehi, UT 84043, USA


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© 2012 Teitelbaum et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the 76-6326 Kaheiau St; Kailua Kona, Hawaii USA 96740; Fax: 808-329-5534; E-mail: Endfatigue@aol.com


Abstract

Objectives:

Chronic Fatigue Syndrome and Fibromyalgia (CFS/FMS) are debilitating syndromes affecting ~2- 4% of the population. Although they are heterogeneous conditions associated with many triggers, they appear to have the common pathology of being associated with impaired energy metabolism.

As D-ribose has been shown to increase cellular energy synthesis, and was shown to significantly improve clinical outcomes in CFS/FMS in an earlier study, we hypothesized that giving D-ribose would improve function in CFS/FMS patients.

Design, Location, and Subjects:

An open-label, unblinded study in which 53 US clinics enrolled 257 patients who had been given a diagnosis of CFS/FMS by a health practitioner.

Interventions:

All subjects were given D-ribose (Corvalen™), a naturally occurring pentose carbohydrate, 5-g TID for 3 weeks.

Outcome measures:

Keywords: Fibromyalgia, Chronic Fatigue Syndrome, Energy Levels, D-Ribose, Pain, pain Relief.